FREQUENTLY ASKED QUESTIONS
OPIOID F. A. Q.
NARCAN F. A. Q.
What is fentanyl?
Fentanyl is a Schedule II controlled substance about 100 times more potent than morphine. 42% of the pills tested for fentanyl contained at least 2 mg (3 grains of salt), a potentially lethal dose. Even in small doses, it can be deadly. Fentanyl and other synthetic opioids are the most common drugs involved in overdose deaths. Over 150 people die every day. Drugs may contain deadly levels of fentanyl, and you wouldn’t be able to see it, taste it, or smell it.
Can you overdose by coming into contact with fentanyl?
(For example, by touching money or a doorknob with fentanyl on it.)
Can a person that is addicted to opioids just stop if they try hard enough?
No. Some people think that an opioid addiction is just psychological or a weakness of character, and that people who are addicted simply don’t have the willpower to stop. But it’s more complicated than that. Long-time use of opioids (legally or illegally) alters brain functioning. It causes chronic and lasting changes in the brain reward system, causing the person to feel less motivation and get less pleasure from other, naturally occurring rewards. Opioids become the primary reward and the primary focus of the person’s life, and they need more of it to activate the reward system. Additionally, when a person does try to quit, they will likely experience withdrawal symptoms such as abdominal cramping, diarrhea, dilated pupils, goosebumps, nausea, and vomiting.
Is opioid withdrawal life-threatening?
Yes, opioid withdrawal syndrome is a life-threatening condition resulting from opioid dependence. Opioid withdrawal occurs when a patient who is dependent on opioids suddenly reduces or stops taking opioids.
Is there a way to treat opioid use disorder and/or opioid withdrawal syndrome?
Yes, when opioid withdrawal signs are present, pharmacological management of opioid withdrawal is needed. Long-term opioid replacement is accomplished using methadone or buprenorphine.
What is methadone?
Methadone is a synthetic opioid agonist that eliminates withdrawal symptoms and relieves drug cravings by acting on opioid receptors in the brain, the same receptors that other opioids activate. Although it occupies and activates these opioid receptors, it does so more slowly than other opioids and, in an opioid-dependent person, treatment doses do not produce euphoria. It has been used successfully for more than 40 years to treat opioid use disorder and must be dispensed through specialized opioid treatment programs.
What is buprenorphine?
Buprenorphine is a partial opioid agonist, meaning that it binds to those same opioid receptors but activates them less strongly than full agonists do. Like methadone, it can reduce cravings and withdrawal symptoms in a person with an opioid use disorder without producing euphoria, and patients tend to tolerate it well. Research has found buprenorphine to be similarly effective as methadone for treating opioid use disorders, as long as it is given at a sufficient dose and for sufficient duration.
What is Naltrexone?
Intramuscular extended-release naltrexone is a medication approved by the Food and Drug Administration (FDA) to treat both opioid use disorder (OUD) and alcohol use disorder (AUD). Naltrexone can be prescribed and administered by any practitioner licensed to prescribe medications and is available in a pill form for AUD or as an extended-release intramuscular injectable for AUD and OUD. Naltrexone is not an opioid, is not addictive, and does not cause withdrawal symptoms with stop of use. Naltrexone blocks the euphoric and sedative effects of opioids such as heroin, morphine, and codeine. Naltrexone binds and blocks opioid receptors and reduces and suppresses opioid cravings. There is no abuse and diversion potential with naltrexone.
What is Narcan (naloxone)?
Naloxone is a medicine that rapidly reverses an opioid overdose. It is an opioid antagonist. This means that it attaches to opioid receptors and reverses and blocks the effects of other opioids. Naloxone can quickly restore normal breathing to a person if their breathing has slowed or stopped because of an opioid overdose.
Is Narcan (naloxone) a drug?
Narcan nasal spray was first approved by the FDA in 2015 as a prescription drug. In accordance with a process to change the status of a drug from prescription to nonprescription, the manufacturer provided data demonstrating that the drug is safe and effective for use as directed in its proposed labeling. The manufacturer also showed that consumers can understand how to use the drug safely and effectively without the supervision of a healthcare professional.
Can someone get high on Narcan or overdose on it?
Naloxone has no effect on someone who does not have opioids in their system, and it is not a treatment for opioid use disorder. There are minimal risks associated with naloxone. Naloxone is not a controlled medication. It has no street value, and you cannot become addicted to it. If used by a person who doesn’t use opiates, at worst it might make them uncomfortable. The only exceptions would be for an individual who had an allergic reaction to naloxone or a woman who was pregnant or nursing.
Can Narcan prevent deaths or reverse overdoses caused by substances other than opioids?
No. Naloxone does not prevent deaths caused by other drugs such as benzodiazepines (e.g., Xanax, Klonopin, and Valium), bath salts, cocaine, methamphetamine or alcohol. Always call 911 if you suspect an overdose, because the victim may need other care.
Does having Narcan available encourage people to misuse substances?
No. Research studies have found that making naloxone available does not encourage people to use opioids more. In fact, some studies have shown that naloxone results in a decreased use of opioids. The majority of respondents in a survey felt that they would not inject more heroin despite having naloxone: “I’d just do my normal dose; don’t want to be dope-sick from naloxone”; “You’re not trying to kill yourself; you know your limits.”
What is the difference between Narcan and Kloxxado?
Kloxxado has 8 mg of naloxone versus Narcan has 4 mg of naloxone nasal spray. With Kloxxado you’re getting twice as much naloxone per dose. This is important because 34% of opioid overdose reversals involved at least 2 doses of naloxone.
Is there any biblical support for the use of Narcan?
In Judaism, there is an obligation to save a life in jeopardy referred to as pikuach nefesh. This obligation, which in Hebrew means “saving a soul,” is considered a major value to uphold. Pikuach nefesh is derived from the biblical verse, “Neither shall you stand by the blood of your neighbor” (Leviticus 19:16). According to pikuach nefesh a person must do everything in their power to save the life of another. LEARN MORE
Additionally, there is a story in the New Testament that also supports saving a life whenever possible. In Luke 10:30-36, Jesus told a story of a man who was traveling and was attacked by robbers. The robbers left him naked and half-dead on the side of the road. A priest and later a Levite came down that road but crossed the road when they saw him and did not help him. It was not until a Samaritan came across the man that he received any help. After telling the story, Jesus posed the question of which of the three passersby’s was a neighbor to the injured man. This parable is where the popular phrase “good Samaritan” came from and reflects the biblical support of saving a life when possible.
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